glutathione synthesis rate-limiting step in Cancer Cells | Biochemistry (Moscow) The Role of Glutathione Metabolism

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For cretinism in iodine-deficient areas, Se supplementation should not be promoted prior to iodine supplementation or when there is no plan for iodine supplementation, as stated by the American Thyroid Association, The differential intakes of iodine, Se, or both in different regions must be considered before any action for Se supplementation is taken ( 3.4 Se and thyroid tumors The incidence of thyroid cancer has been on the rise in the past decades, increasing faster than any other cancer ( In addition to increasing the risk of disease, Se deficiency is also strongly associated with the progression of thyroid cancer

That framing matters because bioavailability is often used imprecisely

Interstrand crosslink repair A repair pathway that removes DNA bases from complementary strands that are covalently crosslinked