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Optical sensing methods including surface-enhanced Raman spectroscopy (SERS), colorimetric assays, and fluorescence based detection face practical limitations in wearable applications [Figure 3A] [106,107]

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doi: 10.3389/fnins.2021.630016 Received 16 November 2020 Accepted 20 January 2021 Published 05 February 2021 Volume 15 - 2021 Edited by Matthew William Pitts, University of Hawaii at Mnoa, United States Reviewed by Frederick P