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The mechanistic origins of all these defects are not well understood, and no placebo-controlled randomized clinical trial (RCT) has successfully shown the reversal of multiple such age-associated defects in OA

a combination of 1mM IBMX, 1 M dexamethasone, and 10 g/ml of insulin in media were added to fully confluent 3T3-L1 fibroblasts for three days (days 03) to initiate differentiation
doi: 10.1021/acschemneuro.1c00516 193 YooMHGuXXuXMKimJYCarlsonBAPattersonADet al

This prevents scar tissue formation while boosting dermal density
