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For example, upregulation of inflammatory pathways such as the IL-6/STAT3 axis plays an important role in the survival of DTP cells ( 3.1.3 Translational reprogramming The emergency of DTP cells is closely related to translational reprogramming, particularly the role of translation regulatory factors such as eIF4A (Figure 1)

Given the susceptibility of the brain to radiation-induced oxidative stress, understanding the role of GPX4 in ferroptosis becomes paramount for developing potential therapeutic interventions

Gu et al, 2021

Recent advances in drug delivery via the organic cation/carnitine transporter 2 (OCTN2/SLC22A5) Expert Opinion on Therapeutic Targets