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Yes, B12 supplementation is appropriate if deficiency is confirmed, and the MHRA recommends monitoring B12 levels in people on long-term metformin

It activates melatonin secretion, leading to a decrease in the incidence of tumor growth, as there is an inverse relationship between melatonin secretion and malignant tumor growth

Allergic reactions are extremely uncommon but require immediate medical attention

If the temperature dropped to 0-2C but the solution did not freeze, it is fine, simply adjust the refrigerator setting
