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Some of the critical enzymes in HDL include glutathione peroxidase 1 (GPx), paraoxonase 1 (PON1), and platelet activating factor acetylhydrolase (PAF-AH, also called lipoprotein-associated phospholipase A 2 , Lp-PLA 2 )

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It is the most widely accepted theory which postulates that during the development of the melanocytic tumour, there is a migration of nevus cells from the epidermis to dermis and which then starts to proliferate