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Once released, histamine has multiple pleiotropic functions within the developing and mature central nervous system, including regulating neuronal excitability and neurotransmission (Haas et al., 2008), synaptic plasticity (Han et al., 2020), and immunomodulation (Forsythe, 2019) and has a functional role in modulating many aspects of behavior including learning, cognition, wakefulness, attention and memory (Haas and Panula, 2003