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Description
The reason is mechanical

Wessel (Viatris, Germany)

First, the outer layer of the hard gelatin capsules was covered with hydroxypropyl methylcellulose phthalate (HP55), an enteric polymer sensitive to pH, with a pK a of 5.50

Also, the strong stacking of those N-doped graphite carbon in nanozymes generally induces the frustrated diffusion of bio-substrates to metal sites