5-amino-1mq nnmt inhibition mechanism Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation 5-Amino-1MQ for Fat Metabolism —
Description
GIP receptor agonism further enhances insulin release and may improve fat metabolism
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
doi: 10.1007/s00125-014-3490-7
Selective and potent inhibitors available for cellular and animal studies will have a high impact on the elucidation of the underlying mechanisms of NNMT-regulated diseases, which would ultimately lead to the identification of new therapeutic strategies
