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To verify the binding capability of p53 TAD PEP to the FOXO4 FHD, we performed FPA

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Since it is difficult to modify intrinsic GSH reactivity in the presence of cellular GST, warheads with reduced reactivity are preferred to minimize the non-specific covalent binding burden on proteins, which correlates with the in-vitro reaction rate of the drug and GSH [105,106]
ACS Nano 16 (7), 1090410917
