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For diabetic patients less than 35 years of age, the mortality for ischemic heart disease is increased 30-fold when compared to the general population.71 Microvascular complications account for the major causes of development of blindness, end-stage renal disease and peripheral nerve dysfunction

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Two other studies demonstrated that MAPK pathway inhibitors in combination with HDACi suppressed cAMP mediated resistance in melanoma cells [109] and that pre-treatment of platinum drug resistant ovarian cancer cells with HDACi and methylation inhibitors sensitized these cells to cisplatin-mediated cell death [110]