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sustained growth-hormone-axis stimulation also carries a theoretical, class-wide concern for worsened insulin resistance, a recognized effect of excess growth hormone exposure generally Evidence snapshot: The strongest available evidence is a small 1997 randomized, placebo-controlled human trial (19 adults aged 55-71) testing a closely related GHRH(1-29) analog over 16 weeks, which found increased IGF-1 in both sexes, a significant lean-mass increase in men only, and increased skin thickness in both sexes

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Evoked pain encompasses allodynia which, is a painful perception in response to non-noxious stimuli and hyperalgesia, which is an exaggerated response to a noxious stimulus [2]

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Subsequent in-vitro work has examined its action on tendon-fibroblast outgrowth, gastrointestinal-tract protection, and angiogenesis pathways via VEGFR2/eNOS signaling

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