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Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

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Individual response varies based on factors including metabolic rate, insulin sensitivity, activity level, and previous peptide experience

This hypothesis might have been corroborated by the observation that the levels of the cleaved forms of caspase-3 and PARP, both proteins which may be associated with programmed cell death, seemed to be reduced after introduction of AHK-Cu