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According to the EORS theory, aging is associated with sedentary behavior, which leads to an oxidized redox shift characterized by an extracellular decrease in the ratio of cysteine to cystine and an intracellular decrease in the ratio of GSH to GSSG and NAD(P)H to NAD(P) (419)

Moreover, the Left Atrioventricular Coupling Index (LACI) and Right Atrioventricular Coupling Index (RACI) are not related to myocardial iron load, but they are significantly increased in patients with cardiac complications (114)

Hair cells have a build-up of mutations in their mitochondrial DNA at the same time, which eventually sets off apoptotic pathways
