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The regulation of intestinal homeostasis is achieved by the secretion of immunomodulatory metabolites, such as SCFAs, tryptophan and its derivatives, -aminobutyric acid (GABA), bile acids, amino acids, trimethylamine, sphingolipids, bacteriocins, exopolysaccharides, relieving this way neurological disorders, inflammatory bowel, cardiovascular illness, and tumor appearance [97]

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Similarly, some studies have supported its usefulness in respiratory disorders such as COPD and cystic fibrosis, while others have questioned it owing to a lack of long-term evidence and small sample numbers

41589_2021_915_MOESM16_ESM.mpeg Supplementary Video 14 Representative movie for 100 ns MD simulation of oxidized GPX4 U46C-K48A (C46-SOOO-) with the camera zoomed in for a close-up of the active site