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For example, the lysosomal cysteine protease cathepsin B (CTSB) promotes autophagy-dependent ferroptosis via translocation from lysosome into nucleus to cause DNA damage signals and to activate stimulator of interferon response cGAMP interactor 1 (STING1, also known as STING or TMEM173)-dependent DNA sensor pathways (39) ( Figure 2 )

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Sermorelins body composition effects are real but typically smaller, partly because the GH pulse is briefer and partly because the single-pathway mechanism produces less amplitude than dual activation

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