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They interact with neurexins (NRXNs) on the presynaptic cell surface to regulate synaptic differentiation, thereby contributing to the formation of either inhibitory or excitatory synapses ( Among the NLGN isoforms, NLGN1 is predominantly involved in excitatory synapse structure, transmission, and plasticity, but has minimal effects on inhibitory synapses.While its direct link to ASD remains unclear, alterations in NLGN1 expression may contribute to cognitive impairments through disruptions in synaptic plasticity and learning-related neural circuits ( In Nlgn2 R215H mutant mice, inhibitory synaptic transmission is significantly reduced in the prefrontal cortex, accompanied by decreased levels of the GABAA receptor 2 subunit and vesicular transporters

Yet, the impact of SSRI on circulating concentrations of calcium during the peripartum period is still poorly understood

The stabilized NRF2 competes with BTB and CNC homolog 1 (BACH1) for binding to antioxidant response elements (AREs) within the TKT promoter, thereby enhancing TKT transcription [104]

To quantify the concentrations of SAM and SAH using the multiple reaction monitoring (MRM), LC/MS/MS conditions were optimized