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The brain substantia nigra in PD has a high level of expression of the VD metabolizing enzyme and 1 hydroxylase, and VD can stimulate the expression of tyrosine hydroxylase, a key enzyme of dopamine synthesis in PD, which affects the production and turnover of dopamine, therefore, the role of VD in the development process of PD has received increasing attention (85, 86)

In another study, grape pomace-supplemented feed improved the ratio of polyunsaturated to saturated fatty acids and enhanced the oxidative stability of animal products, indicating that a considerable portion of polyphenols retained their bioactivity after digestive processes (357)

Protocol 2: Twice Daily (Split Dose) When: First dose immediately upon waking (fasted)

62 However, when the animals are pretreated with ferrous iron, not only is the nitration pathway enhanced, but LPO suddenly becomes a relevant part of the pathomechanism