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These findings establish PKA as a critical regulator of LD lipolysis via HSL activation, directly connecting this pathway to the superior efferocytic capacity of M2 macrophages

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Neurological manifestations are particularly concerning and may include peripheral neuropathy with paresthesias (tingling and numbness in hands and feet), ataxia, impaired proprioception and vibratory sense, cognitive impairment, memory loss, and in severe cases, subacute combined degeneration of the spinal cord