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Description
It is primarily produced by hepatocytes, although minor amounts are also synthesized by monocytes, macrophages, intestinal epithelial cells, and bronchial epithelial cells ( A1ATD is primarily characterized by two clinical conditions resulting from a pathophysiological mechanism that leads to either gain or loss of function defects

In reserpinized animals, the number of squares crossed, grooming, raising, sniffing, and mobile time were considerably reduced, while the central immobility time was significantly enhanced compared to the control group
Growth and viability analyses Log-phase cells were seeded and treated with varying concentrations of disulfiram for 48 h to generate doseresponse curves
We thank Tuanlao Wang, Yuhong Chen, Shan Jiang, Yun Hong, and members of the Li lab for constructive discussions
