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May Paul J

Finally, we assessed investigator overall improvement as deemed by the study doctor using a 5-point scale: 2 = marked improvement, 1 = slight improvement, 0 = unchanged, 1 = worsening, 2 = marked worsening at the study endpoint (week 12)
Food and Drug Administration (FDA) has approved pregabalin, duloxetine, tapentadol, and the 8% capsaicin patch as drugs for the treatment of painful DPN

Future research should investigate shorter duration supplemental periods of L-carnitine and carbohydrate, while also looking at accumulation in skeletal muscle via biopsies
