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This variant changes evolutionarily conserved glycine to tryptophan and is predicted to be deleterious by SIFT and PolyPhen ( The possibility of intragenic deletions of the SLC22A5 gene was excluded using target oligonucleotide array comparative genomic hybridization (array CGH) according to published procedures 22 (data not shown)

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Summary of L-Carnitine Function: Transports fatty acids into mitochondria for energy

Once formed from dietary methionine, homocysteine can be catabolized to cysteine via the transsulfuration pathway or re-methylated to methionine ( Figure 4 )