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Description
Although generally safe, injections should be used with caution in people with a history of allergic reactions to cobalamin or in people with Leber's disease (hereditary optic neuropathy), as B12 may worsen the condition
GRAS simply means the FDA agrees that the substance, at intended use levels as a food additive or supplement, is safe based on common use history or expert opinion and does not pose acute toxicity concerns
In contrast, inhibiting the expression of miR-21a-5p can significantly restore intestinal epithelial cell damage in mice
The slow, wall-method avoids both problems
