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High fever with chill Increasing redness, warmth, swelling, or pain at the injection site A pus-like discharge Red streaks spreading outward from the injection site Common Reasons for Needing an IM Injection Self-administered IM injections may be used for different reasons, including assisted fertility treatments, gender-affirming hormone therapy, vitamin B12 supplementation, and some disease-modifying treatments for autoimmune diseases like rheumatoid arthritis

Severe side effects are rare

RA patients on the other hand, display high levels of autoantibodies in their sera that target joint components including collagen and cartilage, stress proteins, and nuclear proteins (Steiner 2007)