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Other methods utilize reaction of dialkyl tosyloxymethylphosphonate with an appropriate 9-(2-hydroxyethyl)purine derivative (Figure 4A) or reaction of an analogous purine 2-iodoethyl derivative with diethyl hydroxymethylphosphonate (Figure 4B on the example of adefovir)

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For patients with Long COVID and ME/CFS, who are often trapped in a state of chronic, systemic hyper-inflammation, this ability to downregulate pro-inflammatory cytokine cascades while simultaneously supporting targeted antiviral defenses makes L-Lysine a highly valuable therapeutic agent

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