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Canine Degenerative Myelopathy (DM) is a devastating degenerative disease of the spinal cord that can progress rapidly and cause weakness in the hind limbs and eventually paraplegia among genotypically affected dogs

Mitochondrial ROS, particularly O levels, appeared to be elevated in the hippocampal neurons of the Ube3a m-\p+ mouse model, and CoQ10 analogs could attenuate behavioral deficits in these mice [383, 384]

Menopause can induce changes in hormonal status and lipid metabolism

doi: 10.1038/nrurol.2017.98
