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However, the basis for the increased lactate and pyruvate, in some instances, may relate to non-mitochondrial processes such as glycolysis as is suggested by the absence of increased alanine and TCA intermediates noted in some other biomarker clusters (Figure 5, group 4)

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This cascade can exacerbate neurodegeneration, particularly after chronic or high-dose administration (Liu et al., 2013)

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