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Animal mitochondria

ALS pathology involves degeneration of upper and lower motor neurons, misfolded protein accumulation (e.g., TDP-43), mitochondrial dysfunction, oxidative stress, neuroinflammation, and excitotoxicity [100]

To provide a user-friendly access to this dataset to the scientific community, we used the 10 Genomics LoupeR package to generate a CLOUPE file that can be easily imported into the 10 Genomics Loupe Browser for data visualization and further exploration (See below Methods and Data availability sections)

However, another randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for five weeks significantly improved neuropathic symptoms (77)