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Description
In the TME, despite various ammonia clearance mechanisms, rapidly proliferating cells, particularly tumor and immune effector cells, have a heightened demand for -KG derived from glutamine breakdown to fuel the TCA cycle, leading to substantial free ammonia production (103)
Engineering Robust and Tunable Spatial Structures with Synthetic Gene Circuits

Early human trials have explored its effects in mitochondrial-related dysfunction studies

It will not only bring better treatment experience for patients, but also promote new breakthroughs in the field of anti-cancer therapy
