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In the TME, despite various ammonia clearance mechanisms, rapidly proliferating cells, particularly tumor and immune effector cells, have a heightened demand for -KG derived from glutamine breakdown to fuel the TCA cycle, leading to substantial free ammonia production (103)

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Engineering Robust and Tunable Spatial Structures with Synthetic Gene Circuits

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Early human trials have explored its effects in mitochondrial-related dysfunction studies

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It will not only bring better treatment experience for patients, but also promote new breakthroughs in the field of anti-cancer therapy

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