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It is most effective when applied 30 to 40 minutes prior to the procedure

Investig Ophthalmol Vis Sci 44(1):290299 Drolet DW et al (2000) Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys

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10.1016/S0024-3205(03)00489-2
