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Invalidation of Gstp1/2 impairs hepatocyte proliferation In WT mice, the percentage of 5-bromo-2-deoxyuridine (BrdU)-positive hepatocytes increased at 40 h to reach a peak 48 h after PH

Neumann A, Wohlfarth G, Diekert G (1996) Purification and characterization of tetrachloroethene reductive dehalogenase from
Reduced glutathione predominates under physiological conditions and possesses antioxidant and detoxification functions

Glutathione undergoes a reaction with the toxic substances, facilitated by enzymes such as glutathione S-transferases, to form a conjugate known as a glutathione adduct, which is then further metabolized in the liver to form mercapturic acid, a water-soluble compound that can be easily excreted through the urine