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Additionally, trials of oligonucleotide therapeutics and experiments with some small-molecule NNMT inhibitors in vitro and in preclinical animal models have validated NNMT as a promising therapeutic target to prevent or treat obesity and associated T2D

While global Nrf2 activation may be beneficial, its specific effects in different cell types (e.g., potentially promoting ferritinophagy in macrophages) require careful consideration

Routine liver function testing during the initial months of treatment is recommended to detect early signs of toxicity[21-23]