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10.20517/evcna.2021.07 218 ZhengL.HuangM.LiuY.BaoQ.HuangY.YeY.et al (2024)

demonstrate that primary mouse and human hepatocytes can undergo pyroptosis with subsequent release of NLRP3 inflammasome proteins, which activates HSCs with increased secretion of IL-1 and -SMA expression [159]

Acute models Formalin Formalin injection into temporomandibular joints and maxilla induces acute orofacial inflammatory pain[319, 320], nociceptive behavior and acute GLT-1 downregulation in the hippocampus and anterior cingulate cortex (ACC), important areas of pain regulation

In much of the clinical research, TB-500 is described as systemic supportmeaning its often framed as a peptide that can influence broader recovery signaling rather than only localized tissue effects
