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Thus, GPx4 activity is a central molecular switch in the ferroptosis pathway, and the System XcGSH-GPx4 axis is also a central pathway in the ferroptosis pathway, in which a key member, inhibitory SLC7A11 (solute carrier family 7 member 11), inactivates GPx4 and increases lethal reactive oxygen species by blocking the entry of cysteine into the cell, thereby reducing GSH synthesis and ultimately inducing ferroptosis

Part 1: Relevance for autism

Here we identify INTS12, a flexible, poorly characterized subunit of the Integrator complex, as a key mediator linking RSR to TC-NER

The mutant exhibited a 7 day earlier flowering time than the WT, with mean days to flowering of 44.1 and 51.1 days, respectively (Fig