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As regards cell biochemical markers, in the uroli-thiasis model, erastin significantly reduced the antioxidant capacity of HK-2 cells, leading to an increase in the levels of mitochondrial membrane potential, lipid peroxidation and ROS
It activates the MT1/SIRT1/Nrf2 pathway, increasing expression of heme oxygenase-1 (HO-1) and GPx, which protect against lipid peroxidation
Research on depressed patients found that low NPY levels correlate with suicidal ideation, suggesting that NPY deficiency may identify particularly vulnerable individuals
Cytokine 111, 5862
