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While water-soluble drugs can be easily excreted through the kidneys, lipophilic drugs are more difficult to excrete in an aqueous solution and have the potential to accumulate in tissues such as adipose
Brain Res Rev 39:2954 Fogazzi DV, Neary JP, Sonza A et al (2020) The prefrontal cortex conscious and unconscious response to social/emotional facial expressions involve sex, hemispheric laterality, and selective activation of the central cardiac modulation
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