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There was no difference in incidence in diarrhea between the two groups, but severe diarrhea was seen in 69% of the placebo group versus no patients in the glutamine group

Targeted and non-targeted metabolomics analysis All sample preparation and instrumental analyses for targeted and non-targeted metabolomic analyses were conducted following the procedures outlined in our previous study 13 , with the exception of the analysis of tricarboxylic acid (TCA) metabolites, which were investigated using our validated in-house method

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Genital lesions, especially those occurring in the vulva, often show more prominent atypical features, such as moderate to severe cytologic atypia (epithelioid cells with prominent nucleoli) and occasional pagetoid spread