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Copy-number amplifications of serine- and glycine-synthesis genes and genetic alterations in common oncogenes and tumour-suppressor genes enhance serine and glycine synthesis, resulting in high production and secretion of these oncogenesis-supportive metabolites

[13] Published studies co-administering BPC-157 with NOS inhibitors have reported that the inhibitor attenuates BPC-157s effects supporting NO-dependence of part of the peptides biological activity but these studies have not fully resolved whether sustained or high-level NO system modulation through prolonged BPC-157 exposure produces effects on blood pressure regulation, vascular function, or other NO-dependent physiological processes

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