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Increased inactivation of cisplatin by thiol-containing proteins is an important mechanism for tumor resistance, as showed for cervical cancers, osteosarcoma and glioblastoma cells 4,14,15,28

The walnut extract was reported to reduce reactive oxygen species (ROS) and nitric oxide (NO) formation as well as restrict the depletion of striatal DA and its metabolites, resulting in a considerable improvement in PD movement abnormalities in a mouse model of Parkinsons disease (Choi et al., 2016)

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Fibroblast activation protein (FAP), fibronectin, CD44, and integrins are overexpressed in these cells