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Abnormally elevated levels of DRP1 not only cause mitochondrial fission, mitochondrial fragmentation, and decreased efficiency of mitochondrial ATP production but also impede glucose uptake (104) and glucose-stimulated insulin secretion by inhibiting the translocation of the insulin receptor substrate 1-protein kinase B (IRS1-Akt) pathway and glucose transport proteins in mouse pancreatic -cells (105)

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Planta 218 , 114 (2003)

Bei allen Carnitin-Zyklusdefekten, mit Ausnahme des CPT I-Mangels, ist die Konzentration von freiem Carnitin im Blut (Serum) vermindert