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However, like other TKIs, lenvatinib often causes adverse drug reactions such as hypertension, diarrhea, proteinuria, and fatigue, which may lead to dose interruption or discontinuation (Kudo et al., 2018), (Kim et al., 2021)
Targeted therapy usually has a profound immunomodulatory effect on the TME, so targeted therapy combined with immunotherapy should be a strong combinational therapeutic strategy 201,202
Your doctor will show you the correct site and technique for safe administration
IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis J Immunol 1998 161 : 28632872 Singh S, Aggarwal BB
