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It has previously been observed that increased GSK-3 expression and activity in cell and mouse models of AD are associated with the upregulation of p-tau at Ser396 and Ser404, accompanied by a high rate of apoptosis [20]

However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice

Two types of vaccines are under investigation: tumor cell vaccines (composed of actual cancer cells, sometimes the patients own) and antigen-based vaccines (target specific proteins expressed by the tumor cells) (Brahmer 2013)
