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Not as yet well understood is the fact that the E-4 isoform confers increased susceptibility to and decreased age of onset of the late-onset form of Alzheimer disease
[DOI] [PubMed] [Google Scholar] 202.Vuong K., Armstrong B.K., Weiderpass E., Lund E., Adami H.O., Veierod M.B., Barrett J.H., Davies J.R., Bishop D.T., Whiteman D.C., et al
Pharmacological chaperones can increase stability and membrane maturation of selected mutant OCTN2 transporters [148]
and heart and muscle function, through its role in the production of creatine
