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doi: 10.1089/ars.2013.5554 54
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While positive advances have been made, there have been reports of adverse effects leading to autoimmune pathologies (174)

Due to the relatively constitutive activity and the membrane permeability of H 2 O 2 , NOX4-derived signals can integrate across subcellular compartments to modulate transcriptional responses for adapted metabolic homeostasis [32, 33]
