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Using combined semiempirical quantum mechanical (QM)/molecular mechanical (MM) simulations, we investigated the reaction between afatinib, the first TCI drug for cancer treatment, and the front-pocket cysteine Cys797 in EGFR, which has been suggested as unreactive in a recent study

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Endothelial dysfunction, marked by reduced nitric oxide bioavailability, is a known factor in cardiovascular disorders

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