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A single sentence in the 52-page patent spells this out: Heme-containing proteins also can be recombinantly produced using polypeptide expression techniques and can be grown in the cells of bacteria, insects, fungi, plants, or mammals
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Agar JN, Krebs C, Frazzon J et al (2000) IscU as a scaffold for ironsulfur cluster biosynthesis: sequential assembly of [2Fe2S] and [4Fe4S] clusters in IscU
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