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Importantly, we did not observe sex-related differences in circulating IGF-1 levels in the studied groups, and serum IGF-1 levels significantly correlated with age (Fig

Data-driven adjustments are key

Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization
