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Importantly, we did not observe sex-related differences in circulating IGF-1 levels in the studied groups, and serum IGF-1 levels significantly correlated with age (Fig

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Data-driven adjustments are key

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Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

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In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization

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