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Avapritinib versus placebo in indolent systemic mastocytosis

These cases often involve an interplay between neuroautoimmunity and immune hypersensitivity, with mast cells amplifying the inflammatory response to microbial triggers

For reference, these are the Recommended Dietary Allowances (RDA) for vitamin B12 by sex and age group indicating the daily amount needed for healthy individuals ( Men 1418: 2.4 mcg Men 19+: 2.4 mcg Women 1418: 2.4 mcg Women 19+: 2.4 mcg During pregnancy: 2.4 mcg During lactation: 2.8 mcg SUMMARY The RDA for vitamin B12 for most people is 2.4 mcg per day

Some patients experience anxiety as a less common but documented side effect, likely related to appetite suppression affecting energy intake and blood sugar patterns