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These reactions range from mild to noticeable discomfort but theyre typically manageable without medical intervention

Given the similarities between POEMS syndrome and plasma cell dyscrasias such as multiple myeloma, it could be postulated that the mechanisms in POEMS syndrome causing vitamin B12 deficiency may be similar

This clinical observation is possibly because the methylcobalamin delivered by this method is better absorbed into the bloodstream, or it is more bio-available, or the effect is more noticeable because of the constantly higher blood level

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