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Athletes report shortened recovery periods after high-intensity workouts or eccentric training phases

The R248W and R273H mutations attribute Mre11 nuclease-binding capacity to the p53 protein to prevent association of the Mre11-Rad50-NBS1 (MRN) complex with DNA double-strand breaks, thereby impairing ataxia-telangiectasia mutated (ATM) activation and the DNA damage response (Calheiros et al